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As a result, there are repeated reports of severe nerve disorders after nitrous oxide anaesthesia, which however can be remedied with B12 supplements if taken promptly afterwards (65, 66)

This leads to the major motor symptoms of tremor, bradykinesia, and rigidity, along with postural difficulties, which are classical for PD (Obeso et al., 2017)

In addition, Tim-AIII-mediated GPX4 ubiquitination and degradation were abrogated when HSP90 was knocked down by HSP90-shRNA transfection ( Fig