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Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas)

Inhibition of lipid synthase activity: AOD 9604 reduces the activities of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), and decreases de novo synthesis of fatty acids

Beyond fat metabolism, the same fragment has been probed in unrelated tissues most notably a rabbit osteoarthritis model, where weekly intra-articular injection of AOD-9604, alone or with hyaluronic acid, improved cartilage scores relative to saline

Pregnant patients with B deficiency should be closely monitored and treated appropriately to ensure healthy outcomes