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Studied in models involving sleep architecture, circadian rhythm signaling, and rest-related neurobiology

Proc Natl Acad Sci USA 106:27702775

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[12] [13] The systemic availability of orally administered glutathione is poor

Therefore, when proline is the only carbon and nitrogen source, the gdh3 / gdh3 cells would probably be experiencing a serious shortage of the NAD + required to catabolise proline via the PUT pathway
