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This is the first demonstration that an extracellular nutrient, methionine, can supplant the need for intracellular use of NADPH by GR or TrxR1 and sustain cytosolic redox homeostasis in mammalian cells

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To gain a better understanding of the mechanism of resistance and of possible candidate genes that are involved in the Sw-7 resistance response, several categories of genes, including those encoding nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins, defense-related proteins, transcription factors, protein kinases, as well as those related to phytohormone signaling, cell wall, photosynthesis, gene silencing, and microRNA target genes, were further analyzed as follows

This process requires a significant amount of energy and produces its own metabolic byproducts