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Description
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

High doses of Vitamin B6 and B12 may also lead to an imbalance in the gut microbiome, which can cause inflammation in the skin and contribute to the development of Acne

Prog Nucleic Acid Res Mol Biol 2001;70:33-75
The presence or absence of bacteria-derived hydrogen sulfide may also be a factor that determines the immune response detected in different studies

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