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31-33 However, it remains unknown whether specific patient populations could benefit more from NAC therapy than others

Nrf2 Signaling Nrf2-related factor 2 is a member of the Cap n Collar (CNC) family of basic leucine zipper (bZip) transcription factors that include nuclear factor-erythroid factor 2 (NF-E2), Nrf1-3, and broad-complex, tramtrack, and bric-a-brac (BTB) and CNC homolog 1 (Bach 1) and Bach 2

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however, emerging study results suggest that regulation of one or more of these cell death signaling pathways is a measure to modulate cellular responsiveness to chemotherapeutic agents