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This proteasomal inhibiting role can lead to a reduced proteasomal elimination of ubiquinated P-I (phosphorylated-inhibitor kappa), inhibiting nuclear translocation of NF-, suppressing NF-B activation and its consequences of tumor necrosis factor alpha (TNF-), and NO production (34, 51, 52)

PMID: 76 ZhiQ

The problem is that Vitamin B12 is water solublemeaning it dissolves in fluidsmaking it particularly difficult for your body to absorb efficiently

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Alabdali, A., et al