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Anyone on long-term metformin, PPIs, or a GLP-1 protocol with significantly reduced intake for months should have B12 checked as part of routine monitoring

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Sajan M, Hansen B, Ivey R et al (2016) Brain insulin signaling is increased in insulin-resistant states and decreases in FOXOs and pgc-1 and increases in A1-40/42 and phospho-tau May Abet Alzheimer development

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Given the H 2 receptor inverse agonism noted with the antipsychotic, clozapine (Humbert-Claude et al., 2012), the authors speculated that famotidines H 2 receptor antagonism might, at least in part, have an antipsychotic effect (Meskanen et al., 2013)