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Specifically, 5-amino-1MQ and 7-amino-1MQ exhibited high passive and active transport across membrane, with no detectable efflux observed in the Caco-2 cell assay

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[57] Additionally, the receptor undergoes unique regulatory processes, including desensitization and internalization that are partly independent of -arrestin, further distinguishing it from other GPCRs and influencing its response to long-term pharmacological modulation
