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The oral formulation's convenience advantage over injectable semaglutide would be even more pronounced in pediatric populations, potentially making orforglipron the preferred first-line pharmacological option for adolescent obesity if efficacy and safety data support its use

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doi: 10.1155/2013/243876 54 BasitFVan OppenLMPESchckelLBossenbroekHMVan-Emst-De-VriesSEHermelingJCWet al

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA: Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria