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The regulation of antioxidative enzymes by ozone, e.g., glutathione peroxidase and reductase, necessary to maintain or restore the glutathione balance, is explained in Figure 8a: Signal transduction is started via the reduction of ozone peroxides by GSH inducing the translocation of Nrf2 into the nucleus, transcription, translation, and finally the protein synthesisin this case antioxidantsproceeds, first proposed by Sagai and Bocci [15,16]