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Therefore, experts advise that someone should taper off caffeine gradually

A biochemical mechanism

But we can say that scientific opinion seems to lean more toward safe than unsafe. For example, in a 2021 Cognitive Vitality Report, the Alzheimers Drug Discovery Foundation points to a short-term study on CB4211 as some evidence for MOTS-cs safety.40 CB4211 is an analog, or synthetic version, of MOTS-c, and so it should theoretically pose a similar set of risks.41 The study in question was a double-blind, placebo-controlled trial in adult humans using both single doses and multiple ascending doses, under which protocol CB4211 was found to be safe and well tolerated.42 Side effects and potential health risks of MOTS-c Even if MOTS-c is as safe as CB4211, clinical researchers and the healthcare providers we know warn that it potentially poses specific health risks

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Apart from the vasoconstrictive effects of norepinephrine, its excessive levels increase metalloproteinase (MMP)-14, which promotes the activation of MMP-2 and MMP-9, dissolving numerous endothelial surface molecules such as syndecan-1, glypican-1 and platelet endothelial cell adhesion molecule-1 (PECAM-1) (Figure 4) [86]