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Both sequestration crises and the acute chest syndrome may be fatal and sometimes require prompt treatment with exchange transfusions

Inflammation Modulation : Studies suggest reduced inflammatory response in injured tissue, which may help limit secondary damage and support recovery after acute injury

A patient has diabetes, neuropathy, or poor circulation (to prevent complications)

PLoS ONE 14 , e0212574 (2019)

The clinical interactions of BC, if any, with orally administered prescription or over-the-counter drugs should be explored regarding the bioavailability and pharmacokinetics, and the possibility of such an interaction should be monitored in patients using synthetic drugs for co-morbid conditions