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It has a distribution coefficient of 1.13310 5 and a pKa of 7.65
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Both compounds are likely to require indefinite administration to sustain weight loss discontinuation studies with GLP-1 agonists (a similar class to cagrilintide mechanistically) show two-thirds of lost weight returns within 12 months of stopping
However, at present it is not known whether surface salt bridges have a strong stabilizing effect on the native structure in proteins (Berger et al
