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Cofactors can be classified into two types: inorganic ions and complex organic molecules called coenzymes

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IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction

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HSF1-activated genes include those encoding cytosolic chaperones, such as HSP40 and -70 members (e.g., HSPA1A, HSPA6, HSPB1, DNAJB1, and DNAJB6), as well as regulators of chaperone activity (AHSA1 and STIP1), as well as some ~100 other targets

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Penfiled, W

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2007;7:S72S77

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