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Initially, trimethyllysine undergoes hydroxylation by trimethyllysine dioxygenase (TMLD), resulting in the formation of hydroxytrimethyllysine
In summary, there is a mechanistic link between TMAO and elevated foam cell generation resulting in atherosclerosis

doi: 10.1002/ctm2.1738 28 GuZZhuWWangWXuYJiangLHuangJet al

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