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A small pilot randomized control study by Marian et al
Glutamine Metabolism Pathways TCA Cycle and IDH2 In the TCA cycle, glutamine-derived -ketoglutarate converts to isocitrate and citrate
The main difference simply comes down to providing building blocks versus providing the finished metabolic product
Philos Trans R Soc Lond Ser B, Biol Sci
That's the practical evidence that the two pathways are additive rather than redundant in humans
