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This enzyme is found to be upregulated in radioresistant NPC, where it enhances the radioresistance of the cancer cells, 477 This enhancement is achieved by promoting the activity of the deubiquitinase OTUB1, which in turn mediates anti-ferroptosis, a process that stabilizes the expression of SLC7A11 and is crucial in human cancer

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Studies in rat liver have shown that alcohol can reduce the GSH transport rate of OGC by altering the physical properties of the inner mitochondrial membrane due to increased cholesterol levels [47]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 138.Simo M, Vaquero L, Ripolles P, Gurtubay-Antolin A, Jove J, Navarro A, Cardenal F, Bruna J, Rodriguez-Fornells A