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67 Tirzepatide initiation dose was 2.5 mg once weekly and increased by 2.5 mg every 4 weeks until reaching the target dose (a lower starting dose and a slower escalation regime compared to the phase 2 trial)

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10.1038/nm0895-804 Summary Keywords nitric oxide, vasodilation, skeletal muscle, mitochondria, redox state, nitrate supplementation, exercise performance Citation Mueller BJ, Roberts MD, Mobley CB, Judd RL and Kavazis AN (2025) Nitric oxide in exercise physiology: past and present perspectives