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4 Mitochondrial DNA: a key player and victim in HIV pathogenesis Mitochondrial DNA (mtDNA) occupies a dual role in HIV pathogenesis: it is both a target for viral-induced damage and a potent activator of innate immune pathways that drive chronic inflammation

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Mechanistically, TSA upregulates transcription factor, Krppel-like factor (KLF4) by inhibiting miR-375, activating the STAT6/monocyte chemotactic protein-induced protein pathway to promote M2 polarization, and simultaneously suppressing the NF-B pathway to reduce inflammation

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