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The number of patients who experience increased blood pressure as they progress through the program is relatively small

210684/Z/18/Z) to RJL, and by a joint BBSRC DTP CASE studentship and an investigator-initiated grant funding from Signify/Philips Lighting to BBO and NM

Cagrilintide vs semaglutide (Wegovy/Ozempic) Mechanism: Cagrilintide: Amylin receptor agonist Semaglutide: GLP-1 receptor agonist Different pathways Weight loss: Cagrilintide alone: 10-12% Semaglutide alone: 10-15% Similar efficacy monotherapy Gastric emptying: Cagrilintide: Very strong delay Semaglutide: Moderate delay Cagrilintide more powerful Side effects: Cagrilintide: More GI effects (stronger gastric slowing) Semaglutide: Moderate GI effects Cagrilintide harder to tolerate for some Availability: Cagrilintide: Investigational (not approved) Semaglutide: FDA approved, widely available Semaglutide easier to obtain currently Combination potential: Synergistic together (CagriSema) 15-25% weight loss combined Best of both mechanisms Verdict: Similar monotherapy efficacy, but combine for maximum results

This is in line with the observations that conditions such as fatigue, headaches, low body temperature, anxiety, panic attacks, PMS, hair loss, depression, low motivation, IBS, insomnia, decreased memory and concentration are all common symptoms in hypothyroidism