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While essential for maintaining cerebral homeostasis, this barrier concurrently limits pharmacological interventions, often resulting in sub-therapeutic drug concentrations [140]

Experimental evidence indicates that Epitalon can restore melatonin synthesis and normalize daily secretion cycles, thereby improving both sleep and overall hormonal balance in aging subjects

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G proteincoupled receptor D