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Studies have shown that SOD advances the reaction between itself and superoxide anions to form H 2 O 2 and O 2 ( O 2 + O 2 + 2H + O 2 + H 2 O 2 ) ( 2 O 2 reacts with iron ions to generate OH in Fenton systems, inducing the production of 5,6-dihydroxycytosine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine, 8-hydroxyguanine (8-OHdG) and 4,6-diamino-5-formamidopyrimidine ( O 2 , and SOD reduces the H 2 O 2 burden borne by aerobic cells by maintaining the activities of peroxidases and CAT ( O 2 is used as an oxidant, it promotes the generation of H 2 O 2 , while SOD prevents chain reactions initiated by O 2 oxidation and reduces the generation of H 2 O 2 (Liochev and Fridovich, 1994)

To prevent clearance from the circulatory system, FeO NPs are surface functionalised with Polyethyleneimine (PEI)

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doi: 10.1111/ppl.12540 229 ZhangJ.WangL

Increased ROS caused by ultraviolet radiation leads to DNA damage and cellular dysfunction [298]