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The most widely practiced staging involves lymph node evaluation, abdominal ultrasound, and chest radiography

A 2016 publication identified additional concerns, such as cosmetic deformity of the arm (Popeye deformity), cramping or soreness in the biceps muscle, and reduced biceps strength, which may affect elbow and forearm movements

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thus, researchers are trying to increase the tumor permeability by replacing antibodies with smaller peptides and aptamers [143, 207]