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However, the overexpression of HDAC2 reduces the expression of BMP-7 and eliminates the protective effect of SFN against STZ/HG/palmitate-induced fibrosis (Kong et al., 2021)
The genetic variations among CC genotypes resulting from this polymorphism witness an impaired binding of ECSOD to the extracellular matrix, leading to lower tissue levels of the enzyme in comparison to individuals carrying CG and GG genotypes (Srheim et al., 2010)
doi: 10.1038/ni.2001
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