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In the US, iron deficiency and iron-deficiency anemia affect 40% and 6% of 12- to 21-y-old US females, respectively, which has been related to a shift in dietary patterns

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The intracellular thiol redox status is described as the ratio of reduced to oxidized forms, GSH/GSSG, showing 100 or more at the steady state but decreasing to 10 or less under oxidative stress conditions [10,11]