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It is postulated that the intermolecular binding interactions between a drug and a CPP are important factors for enhancing the intestinal absorption of macromolecular drugs (Fig

While the data for putrescine levels was consistent with our pharmacological inhibition experiments, it was noteworthy that we observed over 1.5-fold accumulation of N-Acetyl-GABA upon knockdown of SIRT2 in putrescine-treated astrocytes, indicating that SIRT2 was specifically involved in the metabolic conversion of N-acetyl-GABA to GABA (see Fig

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Different methods have been developed for the detection and quantification of carbonylated proteins as commonly used markers of protein oxidation 4,5,6,7

Chang GSH, eumelanin, GSH pheomelanin