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These channels define the pore pathway 47 (Box 1) and are exemplified by claudin-2, which mediates paracellular flux of small cations, such as Na + , and water 42,43,48,49

(3) Alzheimers disease has a multitude of potential causes

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Abbreviations AED antiepileptic drug ANOVA analysis of variance BBB bloodbrain barrier CA1 Region 1 Cornu Ammonis CAT catalase CNF coumarin nasal formulation CT coagulation time EA Eclipta alba FITC fluorescein FTIR Fourier transform-infrared GABA A gamma-aminobutyric acid (GABA) type A receptor GFAP glial fibrillary acidic protein GRP group GSH glutathione H&E hematoxylin and eosin HET-CAM hens egg test choroiallantoic membrane HPLC high performance liquid chromatography HT hemorrhage time ICH International Council for Harmonization of Technical Requirement i.p