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elegans model of PD demonstrated that the compound reduced the formation of intracellular inclusions, improved the motility up to similar levels to the healthy controls, and increased longevity, protecting against aggregation-induced toxicity [300]

Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric crohns disease and murine colitis

Svio ALV, da Silva GN, Salvadori DMF

20 , 21 Much earlier, Selyes concept was born outside of the gastrointestinal tract, in the adrenal gland, and Selye conceptualized the general syndrome of adaptation (i.e., adrenal gland hypertrophy, thymolymphatic involution, and stomach stress ulcers) to achieve general homeostasis in the whole body while the derangement could explain the genesis of many stress-induced diseases