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Experimental studies further show that these fibrils are structurally stable and highly neurotoxic, their introduction into the colon reproduced key motor and cognitive deficits associated with PD [134, 135], underscoring the role of secretase as a molecular link between peripheral inflammation and central neuropathology

10.5504/BBEQ.2013.0061 100 GilbertN

doi: 10.1038/s41598-018-32733-3 158 SinglaRMishraAJoshiRSarmaPKumarRKaurGet al

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