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Duration of action and pharmacokinetics: The AOD9604 half-life is relatively short about 24 hours in humans so the peptide is cleared from the bloodstream fairly quickly after administration
The primary mechanisms behind these effects involve the activation of the caspase-3 and 7 pathways, inhibition of histone deacetylase (HDAC), and an enhancement of cisplatins cytotoxic effects [237]
2021 Feb 26 [cited
The reaction catalyzed by GPATase, being the first committed step of the pathway, represents the primary control point
