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246,247 Some evidence suggests vitamin C supplementation may improve atherosclerosis and other conditions associated with increased risk of venous and arterial clots, but the effect is likely to be mild and of greater importance in those with lower vitamin C levels and higher cardiovascular risk

Retinoids and acids work primarily through exfoliation

For instance, there is some evidence that very high levels of antioxidants could potentially interfere with the effectiveness of certain chemotherapy treatments

However, the difference between them is that in opioid tolerance, an increased amount of opioids is necessary to relieve the pain, whereas in OIH, the same amount of opioid causes paradoxically worse pain