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Metformin may increase the risk of lactic acidosis, so starting the treatment with this agent needs to be preceded by careful analysis of renal, liver or heart function of the patient

Cheng M, Ding F, Li L, Dai C, Sun X, Xu J, et al
However, carnitine is a vital metabolite for the heart as it is necessary for the transfer of long-chain fatty acids across the inner mitochondrial membrane for beta-oxidation
