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Genomics 85:591599

In most patients, the tumor disappeared either entirely or partially

Common effects: Injection-site reactions (mild redness, slight discomfort) most common Transient headaches (resolved without intervention) Mild fatigue in some subjects (usually early in treatment) No serious adverse events reported Laboratory changes: No significant changes in blood glucose or insulin levels No effects on liver enzymes or kidney function No changes in IGF-1 levels (confirming the absence of a GH rise) No clinically significant changes in other laboratory parameters Phase 2 trials (overweight/obese subjects): Efficacy trials in overweight and obese populations confirmed the favorable safety profile

BMI was calculated as weight in kilograms divided by the height in meters squared