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In another study, metabolome analysis of 110 metabolites in CD44v9-positive and CD44v9-negative tumors suggested that CD44v9 could increase pentose phosphate pathway flux and sustain glutathione expression in gastric cancer cells [121]

[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Wu G.D., Chen J., Hoffmann C., Bittinger K., Chen Y.-Y., Keilbaugh S.A., Bewtra M., Knights D., Walters W.A., Knight R., et al

Individuals with B12 deficiency (caused by diet, medical conditions, or age) Vegans and vegetarians (since B12 is mainly found in animal products) People with pernicious anemia Individuals with malabsorption issues Older adults (due to decreased stomach acid production with age) Note: While B12 injections can be highly beneficial for those with a deficiency, they are not typically necessary for people with adequate levels of B12 from their diet or supplements