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Major efforts have focused on the most appropriate way to deliver a functional CFTR gene into respiratory epithelia

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Glutathione has been reported as essential element to counteract negative influences

the first is the inositol-requiring enzyme 1 (IRE1), IRE1 is the main isoform, which presents phosphorylase activity and endoribonuclease activity, causes mRNA degradation and the alternative splicing of X-box binding protein 1 (XBP1s) upregulated the expression of the machinery for protein synthesis and factors related to protein degradation (Maly and Papa 2014)

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