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doi: 10.1016/j.jchromb.2013.01.030

If left untreated, it can get worse

A researcher reading the AOD-9604 literature should weight the single rigorous negative trial far more heavily than the cluster of smaller positive reports, because that is how evidence hierarchy works

The severity and duration of deficiency are perhaps the most significant factors

A recent screening-based study has identified several promising SARM1 inhibitors, including non-competitive inhibitors such as berberine chloride and zinc chloride 233 , suggesting the presence of an allosteric binding pocket that can be targeted for therapeutic development