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Moreover, in contrast to NAC, isoproterenol was still therapeutically effective even being administered in a late phase [110]

This involves upregulating gene and protein expressions and accumulating specific metabolites (Jiang 2023)

22 , 34 , 44 , 118 Vitamin B 12 therapy reduces oxidative damage and inflammation levels, both systemically and in the central nervous system, especially associated with folate

135,136 The underlying mechanism is that these cells lacking IDH2 show enhanced invasive behavior due to the increase in matrix metalloproteases, which depend on the NF-B pathway