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[0312] Additionally chimeric constructs are provided that expand beyond targeted chemotherapy to immunotherapy by incorporating, for example, providing bispecific antibodies comprising an anti-ALPP/ALPPL2 antibody attached to a second antibody that is capable of recruiting and activating immune system components or attached to a moiety that is a checkpoint inhibitor {e.g., anti- CTLA4 {e.g., comprising an ipilimumab variable region), and/or antibodies directed against PD-L1 {e.g., comprising an nivolumab, or pembrolizumab variable region), and/or antibodies directed against PD-L2

Bollino D, Balan I, Aurelian L

This is consistent with the greatest amount of change observed with respect to the max peak wavelength

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The derivatized biological material as the pentafluorobenzyloxime trimethylsilylether (PFBO/TMS) had a molecular ion (557) and mass spectral fragmentation pattern identical to those of authentic PFBO/TMS ether of 5-DHT, but at lower levels due to smaller concentrations of the steroid