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It is important to initiate treatment early while at the same time use caution with these agents to prevent further worsening of the hyperpigmentation

[DOI] [PubMed] [Google Scholar] 65.Gomes B.A.Q., Santos S.M.d., Gato L.d.S., Espndola K.M.M., Silva R.K.M.d., Davis K., Navegantes-Lima K.C., Burbano R.M.R., Romao P.R.T., Coleman M.D., et al

There is no established direct causal link between vitamin B12 and joint pain in medical literature

Muscle diameter was preserved in treated groups, while control rats developed progressive atrophy of the quadriceps

While food alone is rarely enough to correct a significant deficiency, its a vital part of maintaining healthy B12 levels for the long term