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There is growing evidence that immune dysregulation and neuroinflammation are central to its pathogenesis, with the microbiota-gut-brain (MGB) axis playing a critical role

doi: 10.1038/s41590-019-0352-y 13 Galvn-PeaSONeillLA

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An Arabidopsis ( Arabidopsis thaliana ) mutant lacking all three DHARs ( D dhar ), with negligible DHAR activity, was shown to be equivalent to wild-type plants in terms of growth and development, as well as ascorbate levels (Rahantaniaina et al., 2017)

The starting dose is typically 20 units (0.6mg)