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When the activity of free radicals surpasses the vitreous antioxidant defense capacity , it leads to oxidative stress and subsequent damage

While serum total Mg levels are typically normal in hypertensive individuals, defects in Mg homeostasis have been documented [67]

In contrast, the levels of cytokines involved in the control of melanocyte proliferation and differentiation and the inhibition of melanogenesis, IL-17, IL-4 and IL-6, were significantly increased in the vitiligo group compared with the control group

Free Radic Biol Med 94:230242 di Maio R, Mastroberardino PG, Hu X et al (2011) Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1/2 mechanisms [J]