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Elevated levels or unnaturally low levels of Krebs cycle metabolites also indicate mitochondrial dysfunction, often stemming from deficiencies in various nutrients and enzymes that are vital to the health of your mitochondria

and Banerjee et al

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Oncogene (2016) 35(24):32018.10.1038/onc.2015.381 28 LiLDiXWuMSunZZhongLWangYet alTargeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: toward a novel active targeting strategy in breast cancer therapy
