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Collectively, these findings indicate that CIH, SF, and sympathetic hyperactivity synergistically drive TME remodeling, thereby facilitating lung cancer initiation and progression

In a randomized Phase II study in patients undergoing liver transplantation, 30 mg/kg NAC administered 1 h before liver procurement and 150 mg/kg via portal vein in the recipient before liver implantation improved transplant survival by about 20% after one year and limited the risk of primary non-function

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CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

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