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Two health issues that fit this type of description are hip and knee replacements

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PD with RBD (RBD-PD) represents a clinically aggressive subtype characterized by more severe motor and nonmotor symptoms, prominent autonomic dysfunction, and accelerated disease progression

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Huo P., Deng L., Lu J., Kan P., Jing R., and Luo L

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The liver produces procoagulant, anticoagulant, and fibrinolytic proteins, and also removes normal and abnormal clotting factors from the circulation

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The control of ascorbic acid synthesis and turnover in pea seedlings

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