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doi: 10.1111/j.1476-4431.2000.tb00013.x

Additionally, ARID1A gene mutations, affecting the BAF250a component of the switch/sucrose nonfermenting (SWI/SNF) chromatin-remodeling complex, are found in approximately 40% of low-grade and 39% of high-grade EECs (Figure 3) (69)

This high energy demand makes the kidneys vulnerable to stress, and accumulating data suggests that changes in NAD + metabolism are linked to CKD progression 292,295,296

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Involvement of Human Glutathione S-Transferase Isoenzymes in the Conjugation of Cyclophosphamide Metabolites with Glutathione