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Journal of Physiology-Paris

We have shown that TPC-1 cell line did not respond to the RSL3 treatment when compared to BRAF or RAS mutant PTC cell lines, thus confirming that the effects observed in other PTC cell lines is in fact a GPX4-specific process

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Based on these studies, it may be concluded that -synuclein is responsible for both the diminished activity of catalase and the increased formation of hydrogen peroxide, as substantiated by the increased oxidative stress markers in Parkinsons disease