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The primary endpoint in SUSTAIN-6 was the time from randomization to the first occurrence of a major adverse cardiovascular event (MACE), which includes cardiovascular death, non-fatal myocardial infarction (MI), or non-fatal stroke

Off-label use for low-BMI cosmetic weight loss is not supported by the evidence, exposes the patient to real risks (including rapid muscle loss and rebound after discontinuation), and typically isn't covered by insurance

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However, she decided to stop taking the medication in January in preparation of trying to become pregnant

To address this, there have been proposals to prioritize individuals at higher risk of premature death, aligning with ethical principles of equitable care (270)