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In the subgroup analyses, human GLP-1 RAs, but not nonhuman GLP-1 RAs, reduced the risk of MACE in patients with HF (p interaction = 0.11)

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A UCLA study published in ACR Open Rheumatology found that GLP-1 receptor agonists such as semaglutide and tirzepatide may reduce rheumatoid arthritis activity and cardiovascular risk factors in people with obesity, suggesting potential dual benefits for metabolic and inflammatory health.

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