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Strategies to Prevent Weight Regain Long-Term The most effective strategy is continuous therapy rather than on-and-off cycling

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If more blood sugar control is needed, the dose can go up to 1 mg weekly

lifetime decreased medical expense $62K JAMA Health Forum (2025): Showed that the cost per quality adjusted life year (QALY) for tirzepatide (Zepbound) was $197K and the cost per QALY for semaglutide (Wegovy) was $468K

Novo CEO Mike Doustdar told CNBC in February that one of the earliest takeaways from the launch is that the pill appears to be expanding the obesity treatment market, drawing in new patients rather than converting existing ones from injections
